23 Aug Cannabinoids Explained (Part 2): CBD-A (CBD-ACID)
We continue our Cannabinoids Explained series with another compound that exists in the Cannabis sativa plant and seems to exert important therapeutic effects: CBD-a.
CBD-a or CBD-acid is the main form in which CBD exists in the cannabis plant, along with THC-a (THC-acid). CBD is obtained through non-enzymatic decarboxylation from the acidic form of the cannabinoid, this reaction taking place when the compounds are heated.
The decarboxylation procedure is also called “activation”, and requires about 90 minutes when the cannabis infusions are heated at 212° F.
Heating the plant at a lower temperature or for a shorter time may lead to partial instead of full activation; until recently, it’s been considered that this is not desirable or convenient, as it reduces the final amount of CBD obtained from a plant. However, new research suggests that CBD-a may also be of great value for humans.
When this compound was first discovered, it was thought to be a minor cannabinoid, and most producers preferred to decarboxylate CBD-a so as to obtain higher amounts of CBD. Yet, the existing studies are promising, as the acidic form of cannabidiol seems to have anti-inflammatory and anti-proliferative effects, helping in the prevention of inflammation and bacterial infections.
What studies say about CBD-a
Just like CBD, CBD-a is a non-psychoactive compound, so it does not cause one to get high if present in CBD products. This compound is currently investigated for the following applications:
- Inhibition of bacterial growth – the potential anti-bacterial effect of CBD-a is supported by a study published in 2000, conducted by researchers at the Biotech Center, Rutgers University, NJ. The study (“The composition of hemp seed oil and its potential as an important source of nutrition”) highlights the correlation between the levels of CBD-a and the antimicrobial potency of the resulting CBD. According to this paper, a higher concentration of acid cannabidiol will result in a greater antibacterial potency of the final CBD product.
- Reduction of inflammatory processes – the anti-inflammatory effect of CBD-acid seems to be the result of the inhibitory action of this compound on COX-2 (cyclooxygenase-2), compound involved in inflammatory processes and in the metastasis of cancer cells.
- Reduces nausea and vomiting – the anti-emetic effect of CBD-a is supported by two different studies, first one showing that this compound reduces vomiting and nausea by increasing the activity at the 5-HT1Areceptor, and the second one showing that CBD-a can function as an anti-emetic agent, without the involvement of CB receptors.
- Inhibits cancer cell growth – finally, studies suggest that CBDa could inhibit the migration of cancer cells in breast cancer through a mechanism involving the inhibition of cAMP-dependent protein kinase A.